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Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells

Oenothein B is a unique macrocyclic ellagitannin dimer that has been found in various medicinal plants belonging to Onagraceae, Lythraceae, and Myrtaceae, with diverse biological activities. The immunological effects of tannins in terms of cytokine-release from macrophages and monocytes have been di...

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Autores principales: Yoshimura, Morio, Akiyama, Hiroshi, Kondo, Kazunari, Sakata, Kozue, Matsuoka, Hideki, Amakura, Yoshiaki, Teshima, Reiko, Yoshida, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565250/
https://www.ncbi.nlm.nih.gov/pubmed/23344020
http://dx.doi.org/10.3390/ijms14010046
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author Yoshimura, Morio
Akiyama, Hiroshi
Kondo, Kazunari
Sakata, Kozue
Matsuoka, Hideki
Amakura, Yoshiaki
Teshima, Reiko
Yoshida, Takashi
author_facet Yoshimura, Morio
Akiyama, Hiroshi
Kondo, Kazunari
Sakata, Kozue
Matsuoka, Hideki
Amakura, Yoshiaki
Teshima, Reiko
Yoshida, Takashi
author_sort Yoshimura, Morio
collection PubMed
description Oenothein B is a unique macrocyclic ellagitannin dimer that has been found in various medicinal plants belonging to Onagraceae, Lythraceae, and Myrtaceae, with diverse biological activities. The immunological effects of tannins in terms of cytokine-release from macrophages and monocytes have been discussed, while the effects on other immunocompetent cells have been the subject of minimal investigation. We evaluated the immunomodulatory effects induced by tannin treatment in human dendritic cells (DCs), which play a critical role in the initial immune response, by measuring the changes in cytokine production, cell differentiation, and cell viability. Oenothein B showed significant down-regulation of the expression of cell surface molecules, CD1a and CD83, suggesting the inhibition of DC differentiation and/or maturation. The suppressive effect on DCs was associated with the induction of apoptosis without the activation of caspase-3/7, 8, and 9, and this was supported by the morphological features indicating significant nuclear condensation. Oenothein B also markedly suppressed the production of inflammatory cytokines, such as IL-1β and IL-6, in a dose-dependent manner. These data may, in part, be able to explain the traditional use of tannin-containing medicinal plants for the treatment of a variety of inflammatory diseases, including inflammatory bowel disease, celiac disease, and rheumatoid arthritis.
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spelling pubmed-35652502013-03-13 Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells Yoshimura, Morio Akiyama, Hiroshi Kondo, Kazunari Sakata, Kozue Matsuoka, Hideki Amakura, Yoshiaki Teshima, Reiko Yoshida, Takashi Int J Mol Sci Article Oenothein B is a unique macrocyclic ellagitannin dimer that has been found in various medicinal plants belonging to Onagraceae, Lythraceae, and Myrtaceae, with diverse biological activities. The immunological effects of tannins in terms of cytokine-release from macrophages and monocytes have been discussed, while the effects on other immunocompetent cells have been the subject of minimal investigation. We evaluated the immunomodulatory effects induced by tannin treatment in human dendritic cells (DCs), which play a critical role in the initial immune response, by measuring the changes in cytokine production, cell differentiation, and cell viability. Oenothein B showed significant down-regulation of the expression of cell surface molecules, CD1a and CD83, suggesting the inhibition of DC differentiation and/or maturation. The suppressive effect on DCs was associated with the induction of apoptosis without the activation of caspase-3/7, 8, and 9, and this was supported by the morphological features indicating significant nuclear condensation. Oenothein B also markedly suppressed the production of inflammatory cytokines, such as IL-1β and IL-6, in a dose-dependent manner. These data may, in part, be able to explain the traditional use of tannin-containing medicinal plants for the treatment of a variety of inflammatory diseases, including inflammatory bowel disease, celiac disease, and rheumatoid arthritis. MDPI 2012-12-20 /pmc/articles/PMC3565250/ /pubmed/23344020 http://dx.doi.org/10.3390/ijms14010046 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yoshimura, Morio
Akiyama, Hiroshi
Kondo, Kazunari
Sakata, Kozue
Matsuoka, Hideki
Amakura, Yoshiaki
Teshima, Reiko
Yoshida, Takashi
Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells
title Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells
title_full Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells
title_fullStr Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells
title_full_unstemmed Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells
title_short Immunological Effects of Oenothein B, an Ellagitannin Dimer, on Dendritic Cells
title_sort immunological effects of oenothein b, an ellagitannin dimer, on dendritic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565250/
https://www.ncbi.nlm.nih.gov/pubmed/23344020
http://dx.doi.org/10.3390/ijms14010046
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