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Changes in Translational Control after Pro-Apoptotic Stress
In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565257/ https://www.ncbi.nlm.nih.gov/pubmed/23344027 http://dx.doi.org/10.3390/ijms14010177 |
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author | Lasfargues, Charline Martineau, Yvan Bousquet, Corinne Pyronnet, Stéphane |
author_facet | Lasfargues, Charline Martineau, Yvan Bousquet, Corinne Pyronnet, Stéphane |
author_sort | Lasfargues, Charline |
collection | PubMed |
description | In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated. |
format | Online Article Text |
id | pubmed-3565257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-35652572013-03-13 Changes in Translational Control after Pro-Apoptotic Stress Lasfargues, Charline Martineau, Yvan Bousquet, Corinne Pyronnet, Stéphane Int J Mol Sci Review In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated. MDPI 2012-12-21 /pmc/articles/PMC3565257/ /pubmed/23344027 http://dx.doi.org/10.3390/ijms14010177 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Lasfargues, Charline Martineau, Yvan Bousquet, Corinne Pyronnet, Stéphane Changes in Translational Control after Pro-Apoptotic Stress |
title | Changes in Translational Control after Pro-Apoptotic Stress |
title_full | Changes in Translational Control after Pro-Apoptotic Stress |
title_fullStr | Changes in Translational Control after Pro-Apoptotic Stress |
title_full_unstemmed | Changes in Translational Control after Pro-Apoptotic Stress |
title_short | Changes in Translational Control after Pro-Apoptotic Stress |
title_sort | changes in translational control after pro-apoptotic stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565257/ https://www.ncbi.nlm.nih.gov/pubmed/23344027 http://dx.doi.org/10.3390/ijms14010177 |
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