Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2′-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation stu...

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Autores principales: Shen, De-Yang, Juang, Shin-Hun, Kuo, Ping-Chung, Huang, Guan-Jhong, Chan, Yu-Yi, Damu, Amooru G., Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565277/
https://www.ncbi.nlm.nih.gov/pubmed/23271366
http://dx.doi.org/10.3390/ijms14010496
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author Shen, De-Yang
Juang, Shin-Hun
Kuo, Ping-Chung
Huang, Guan-Jhong
Chan, Yu-Yi
Damu, Amooru G.
Wu, Tian-Shung
author_facet Shen, De-Yang
Juang, Shin-Hun
Kuo, Ping-Chung
Huang, Guan-Jhong
Chan, Yu-Yi
Damu, Amooru G.
Wu, Tian-Shung
author_sort Shen, De-Yang
collection PubMed
description Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2′-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed.
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spelling pubmed-35652772013-03-13 Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity Shen, De-Yang Juang, Shin-Hun Kuo, Ping-Chung Huang, Guan-Jhong Chan, Yu-Yi Damu, Amooru G. Wu, Tian-Shung Int J Mol Sci Article Phytochemical investigation of the whole plants of Andrographis echioides afforded two new 2′-oxygenated flavonoids (1) and (2), two new phenyl glycosides (3) and (4), along with 37 known structures. The structures of new compounds were elucidated by spectral analysis and chemical transformation studies. Among the isolated compounds, (1–2) and (6–19) were subjected into the examination for their iNOS inhibitory bioactivity. The structure-activity relationships of the flavonoids for their inhibition of NO production were also discussed. MDPI 2012-12-27 /pmc/articles/PMC3565277/ /pubmed/23271366 http://dx.doi.org/10.3390/ijms14010496 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Shen, De-Yang
Juang, Shin-Hun
Kuo, Ping-Chung
Huang, Guan-Jhong
Chan, Yu-Yi
Damu, Amooru G.
Wu, Tian-Shung
Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
title Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
title_full Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
title_fullStr Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
title_full_unstemmed Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
title_short Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity
title_sort chemical constituents from andrographis echioides and their anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565277/
https://www.ncbi.nlm.nih.gov/pubmed/23271366
http://dx.doi.org/10.3390/ijms14010496
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