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Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles

The interplay of adhesion and phase separation is studied theoretically for two-component membranes that can phase separate into two fluid phases such as liquid-ordered and liquid-disordered phases. Many adhesion geometries provide two different environments for these membranes and then partition th...

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Autores principales: Rouhiparkouhi, Tahereh, Weikl, Thomas R., Discher, Dennis E., Lipowsky, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565373/
https://www.ncbi.nlm.nih.gov/pubmed/23340655
http://dx.doi.org/10.3390/ijms14012203
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author Rouhiparkouhi, Tahereh
Weikl, Thomas R.
Discher, Dennis E.
Lipowsky, Reinhard
author_facet Rouhiparkouhi, Tahereh
Weikl, Thomas R.
Discher, Dennis E.
Lipowsky, Reinhard
author_sort Rouhiparkouhi, Tahereh
collection PubMed
description The interplay of adhesion and phase separation is studied theoretically for two-component membranes that can phase separate into two fluid phases such as liquid-ordered and liquid-disordered phases. Many adhesion geometries provide two different environments for these membranes and then partition the membranes into two segments that differ in their composition. Examples are provided by adhering vesicles, by hole- or pore-spanning membranes, and by membranes supported by chemically patterned surfaces. Generalizing a lattice model for binary mixtures to these adhesion geometries, we show that the phase behavior of the adhering membranes depends, apart from composition and temperature, on two additional parameters, the area fraction of one membrane segment and the affinity contrast between the two segments. For the generic case of non-vanishing affinity contrast, the adhering membranes undergo two distinct phase transitions and the phase diagrams in the composition/temperature plane have a generic topology that consists of two two-phase coexistence regions separated by an intermediate one-phase region. As a consequence, phase separation and domain formation is predicted to occur separately in each of the two membrane segments but not in both segments simultaneously. Furthermore, adhesion is also predicted to suppress the phase separation process for certain regions of the phase diagrams. These generic features of the adhesion-induced phase behavior are accessible to experiment.
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spelling pubmed-35653732013-03-13 Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles Rouhiparkouhi, Tahereh Weikl, Thomas R. Discher, Dennis E. Lipowsky, Reinhard Int J Mol Sci Article The interplay of adhesion and phase separation is studied theoretically for two-component membranes that can phase separate into two fluid phases such as liquid-ordered and liquid-disordered phases. Many adhesion geometries provide two different environments for these membranes and then partition the membranes into two segments that differ in their composition. Examples are provided by adhering vesicles, by hole- or pore-spanning membranes, and by membranes supported by chemically patterned surfaces. Generalizing a lattice model for binary mixtures to these adhesion geometries, we show that the phase behavior of the adhering membranes depends, apart from composition and temperature, on two additional parameters, the area fraction of one membrane segment and the affinity contrast between the two segments. For the generic case of non-vanishing affinity contrast, the adhering membranes undergo two distinct phase transitions and the phase diagrams in the composition/temperature plane have a generic topology that consists of two two-phase coexistence regions separated by an intermediate one-phase region. As a consequence, phase separation and domain formation is predicted to occur separately in each of the two membrane segments but not in both segments simultaneously. Furthermore, adhesion is also predicted to suppress the phase separation process for certain regions of the phase diagrams. These generic features of the adhesion-induced phase behavior are accessible to experiment. MDPI 2013-01-22 /pmc/articles/PMC3565373/ /pubmed/23340655 http://dx.doi.org/10.3390/ijms14012203 Text en © 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rouhiparkouhi, Tahereh
Weikl, Thomas R.
Discher, Dennis E.
Lipowsky, Reinhard
Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles
title Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles
title_full Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles
title_fullStr Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles
title_full_unstemmed Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles
title_short Adhesion-Induced Phase Behavior of Two-Component Membranes and Vesicles
title_sort adhesion-induced phase behavior of two-component membranes and vesicles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565373/
https://www.ncbi.nlm.nih.gov/pubmed/23340655
http://dx.doi.org/10.3390/ijms14012203
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