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Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly
Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1(+/−) mice, impaired behavioral performance and improvement of (18)F-FDG uptake. Furthermore, SNJ1945 improve...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565454/ https://www.ncbi.nlm.nih.gov/pubmed/23390575 http://dx.doi.org/10.1038/srep01224 |
| _version_ | 1782258458359234560 |
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| author | Toba, Shiori Tamura, Yasuhisa Kumamoto, Kanako Yamada, Masami Takao, Keizo Hattori, Satoko Miyakawa, Tsuyoshi Kataoka, Yosky Azuma, Mitsuyoshi Hayasaka, Kiyoshi Amamoto, Masano Tominaga, Keiko Wynshaw-Boris, Anthony Wanibuchi, Hideki Oka, Yuichiro Sato, Makoto Kato, Mitsuhiro Hirotsune, Shinji |
| author_facet | Toba, Shiori Tamura, Yasuhisa Kumamoto, Kanako Yamada, Masami Takao, Keizo Hattori, Satoko Miyakawa, Tsuyoshi Kataoka, Yosky Azuma, Mitsuyoshi Hayasaka, Kiyoshi Amamoto, Masano Tominaga, Keiko Wynshaw-Boris, Anthony Wanibuchi, Hideki Oka, Yuichiro Sato, Makoto Kato, Mitsuhiro Hirotsune, Shinji |
| author_sort | Toba, Shiori |
| collection | PubMed |
| description | Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1(+/−) mice, impaired behavioral performance and improvement of (18)F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1(+/−) mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients. |
| format | Online Article Text |
| id | pubmed-3565454 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35654542013-02-06 Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly Toba, Shiori Tamura, Yasuhisa Kumamoto, Kanako Yamada, Masami Takao, Keizo Hattori, Satoko Miyakawa, Tsuyoshi Kataoka, Yosky Azuma, Mitsuyoshi Hayasaka, Kiyoshi Amamoto, Masano Tominaga, Keiko Wynshaw-Boris, Anthony Wanibuchi, Hideki Oka, Yuichiro Sato, Makoto Kato, Mitsuhiro Hirotsune, Shinji Sci Rep Article Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1(+/−) mice, impaired behavioral performance and improvement of (18)F-FDG uptake. Furthermore, SNJ1945 improved the neural circuit formation and retrograde transport of NFG in Lis1(+/−) mice. Thus, SNJ1945 is a potential drug for the treatment of human lissencephaly patients. Nature Publishing Group 2013-02-06 /pmc/articles/PMC3565454/ /pubmed/23390575 http://dx.doi.org/10.1038/srep01224 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| spellingShingle | Article Toba, Shiori Tamura, Yasuhisa Kumamoto, Kanako Yamada, Masami Takao, Keizo Hattori, Satoko Miyakawa, Tsuyoshi Kataoka, Yosky Azuma, Mitsuyoshi Hayasaka, Kiyoshi Amamoto, Masano Tominaga, Keiko Wynshaw-Boris, Anthony Wanibuchi, Hideki Oka, Yuichiro Sato, Makoto Kato, Mitsuhiro Hirotsune, Shinji Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly |
| title | Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly |
| title_full | Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly |
| title_fullStr | Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly |
| title_full_unstemmed | Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly |
| title_short | Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly |
| title_sort | post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, snj1945 rescued defective function in lissencephaly |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565454/ https://www.ncbi.nlm.nih.gov/pubmed/23390575 http://dx.doi.org/10.1038/srep01224 |
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