Essential Role for Rac1 in Cocaine-Induced Structural Plasticity of Nucleus Accumbens Neurons

Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here, we show that repeated cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. We...

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Detalles Bibliográficos
Autores principales: Dietz, David M., Sun, Haosheng, Lobo, Mary Kay, Cahill, Michael E., Chadwick, Benjamin, Gao, Virginia, Koo, Ja Wook, Mazei-Robison, Michelle S., Dias, Caroline, Maze, Ian, Damez-Werno, Diane, Dietz, Karen C., Scobie, Kimberly N., Ferguson, Deveroux, Christoffel, Daniel, Ohnishi, Yoko, Hodes, Georgia E., Zheng, Yi, Neve, Rachael L., Hahn, Klaus M., Russo, Scott J., Nestler, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565539/
https://www.ncbi.nlm.nih.gov/pubmed/22522400
http://dx.doi.org/10.1038/nn.3094

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