In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

AZ465 is a novel selective transient receptor potential cation channel, member A1 (TRPA1) antagonist identified during a focused drug discovery effort. In vitro, AZ465 fully inhibits activation by zinc, O-chlorobenzylidene malononitrile (CS), or cinnamaldehyde of the human TRPA1 channel heterologous...

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Detalles Bibliográficos
Autores principales: Nyman, Eva, Franzén, Bo, Nolting, Andreas, Klement, Göran, Liu, Gang, Nilsson, Maria, Rosén, Annika, Björk, Charlotta, Weigelt, Dirk, Wollberg, Patrik, Karila, Paul, Raboisson, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565573/
https://www.ncbi.nlm.nih.gov/pubmed/23403691
http://dx.doi.org/10.2147/JPR.S37567

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