Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a class A–class B alignment, and by incorporating maximum lagged cor...

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Detalles Bibliográficos
Autores principales: Vohra, Shabana, Taddese, Bruck, Conner, Alex C., Poyner, David R., Hay, Debbie L., Barwell, James, Reeves, Philip J., Upton, Graham J. G., Reynolds, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565703/
https://www.ncbi.nlm.nih.gov/pubmed/23235263
http://dx.doi.org/10.1098/rsif.2012.0846

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