Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation

Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expr...

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Detalles Bibliográficos
Autores principales: Sturrock, Marc, Hellander, Andreas, Matzavinos, Anastasios, Chaplain, Mark A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565746/
https://www.ncbi.nlm.nih.gov/pubmed/23325756
http://dx.doi.org/10.1098/rsif.2012.0988
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author Sturrock, Marc
Hellander, Andreas
Matzavinos, Anastasios
Chaplain, Mark A. J.
author_facet Sturrock, Marc
Hellander, Andreas
Matzavinos, Anastasios
Chaplain, Mark A. J.
author_sort Sturrock, Marc
collection PubMed
description Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
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spelling pubmed-35657462013-03-06 Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation Sturrock, Marc Hellander, Andreas Matzavinos, Anastasios Chaplain, Mark A. J. J R Soc Interface Research Articles Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment. The Royal Society 2013-03-06 /pmc/articles/PMC3565746/ /pubmed/23325756 http://dx.doi.org/10.1098/rsif.2012.0988 Text en http://creativecommons.org/licenses/by/3.0/ © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Research Articles
Sturrock, Marc
Hellander, Andreas
Matzavinos, Anastasios
Chaplain, Mark A. J.
Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
title Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
title_full Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
title_fullStr Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
title_full_unstemmed Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
title_short Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
title_sort spatial stochastic modelling of the hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565746/
https://www.ncbi.nlm.nih.gov/pubmed/23325756
http://dx.doi.org/10.1098/rsif.2012.0988
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