Cargando…
Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation
Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expr...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565746/ https://www.ncbi.nlm.nih.gov/pubmed/23325756 http://dx.doi.org/10.1098/rsif.2012.0988 |
_version_ | 1782258466696462336 |
---|---|
author | Sturrock, Marc Hellander, Andreas Matzavinos, Anastasios Chaplain, Mark A. J. |
author_facet | Sturrock, Marc Hellander, Andreas Matzavinos, Anastasios Chaplain, Mark A. J. |
author_sort | Sturrock, Marc |
collection | PubMed |
description | Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment. |
format | Online Article Text |
id | pubmed-3565746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-35657462013-03-06 Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation Sturrock, Marc Hellander, Andreas Matzavinos, Anastasios Chaplain, Mark A. J. J R Soc Interface Research Articles Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment. The Royal Society 2013-03-06 /pmc/articles/PMC3565746/ /pubmed/23325756 http://dx.doi.org/10.1098/rsif.2012.0988 Text en http://creativecommons.org/licenses/by/3.0/ © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Research Articles Sturrock, Marc Hellander, Andreas Matzavinos, Anastasios Chaplain, Mark A. J. Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
title | Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
title_full | Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
title_fullStr | Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
title_full_unstemmed | Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
title_short | Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
title_sort | spatial stochastic modelling of the hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565746/ https://www.ncbi.nlm.nih.gov/pubmed/23325756 http://dx.doi.org/10.1098/rsif.2012.0988 |
work_keys_str_mv | AT sturrockmarc spatialstochasticmodellingofthehes1generegulatorynetworkintrinsicnoisecanexplainheterogeneityinembryonicstemcelldifferentiation AT hellanderandreas spatialstochasticmodellingofthehes1generegulatorynetworkintrinsicnoisecanexplainheterogeneityinembryonicstemcelldifferentiation AT matzavinosanastasios spatialstochasticmodellingofthehes1generegulatorynetworkintrinsicnoisecanexplainheterogeneityinembryonicstemcelldifferentiation AT chaplainmarkaj spatialstochasticmodellingofthehes1generegulatorynetworkintrinsicnoisecanexplainheterogeneityinembryonicstemcelldifferentiation |