Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation

Pathogenic amyloid-β peptide precursor (APP) mutations clustered around position 693 of APP—position 22 of the Aβ sequence—are commonly associated with congophilic amyloid angiopathy (CAA) and intracerebral hemorrhages. In contrast, the Osaka (E693Δ) intra-Aβ APP mutation shows a recessive pattern o...

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Detalles Bibliográficos
Autores principales: Kulic, L, McAfoose, J, Welt, T, Tackenberg, C, Späni, C, Wirth, F, Finder, V, Konietzko, U, Giese, M, Eckert, A, Noriaki, K, Shimizu, T, Murakami, K, Irie, K, Rasool, S, Glabe, C, Hock, C, Nitsch, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565767/
https://www.ncbi.nlm.nih.gov/pubmed/23149447
http://dx.doi.org/10.1038/tp.2012.109

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