TGF-beta1 on osteoimmunology and the bone component cells

TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-β1 in the develop...

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Detalles Bibliográficos
Autores principales: Kasagi, Shimpei, Chen, Wanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565958/
https://www.ncbi.nlm.nih.gov/pubmed/23321200
http://dx.doi.org/10.1186/2045-3701-3-4
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author Kasagi, Shimpei
Chen, Wanjun
author_facet Kasagi, Shimpei
Chen, Wanjun
author_sort Kasagi, Shimpei
collection PubMed
description TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-β1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-β1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones.
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spelling pubmed-35659582013-02-11 TGF-beta1 on osteoimmunology and the bone component cells Kasagi, Shimpei Chen, Wanjun Cell Biosci Review TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-β1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-β1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones. BioMed Central 2013-01-15 /pmc/articles/PMC3565958/ /pubmed/23321200 http://dx.doi.org/10.1186/2045-3701-3-4 Text en Copyright ©2013 Kasagi and Chen; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kasagi, Shimpei
Chen, Wanjun
TGF-beta1 on osteoimmunology and the bone component cells
title TGF-beta1 on osteoimmunology and the bone component cells
title_full TGF-beta1 on osteoimmunology and the bone component cells
title_fullStr TGF-beta1 on osteoimmunology and the bone component cells
title_full_unstemmed TGF-beta1 on osteoimmunology and the bone component cells
title_short TGF-beta1 on osteoimmunology and the bone component cells
title_sort tgf-beta1 on osteoimmunology and the bone component cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565958/
https://www.ncbi.nlm.nih.gov/pubmed/23321200
http://dx.doi.org/10.1186/2045-3701-3-4
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