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GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

BACKGROUND: Microglia are resident macrophage-like cells in the central nervous system (CNS) and cause innate immune responses via the LPS receptors, Toll-like receptor (TLR) 4 and CD14, in a variety of neuroinflammatory disorders including bacterial infection, Alzheimer’s disease, and amyotrophic l...

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Detalles Bibliográficos
Autores principales:	Parajuli, Bijay, Sonobe, Yoshifumi, Kawanokuchi, Jun, Doi, Yukiko, Noda, Mariko, Takeuchi, Hideyuki, Mizuno, Tetsuya, Suzumura, Akio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565988/ https://www.ncbi.nlm.nih.gov/pubmed/23234315 http://dx.doi.org/10.1186/1742-2094-9-268

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