microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation

Translation of Hepatitis C Virus (HCV) RNA is directed by an internal ribosome entry site (IRES) in the 5′-untranslated region (5′-UTR). HCV translation is stimulated by the liver-specific microRNA-122 (miR-122) that binds to two binding sites between the stem-loops I and II near the 5′-end of the 5...

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Detalles Bibliográficos
Autores principales: Conrad, K. Dominik, Giering, Florian, Erfurth, Corinna, Neumann, Angelina, Fehr, Carmen, Meister, Gunter, Niepmann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566042/
https://www.ncbi.nlm.nih.gov/pubmed/23405269
http://dx.doi.org/10.1371/journal.pone.0056272

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