Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

Accumulation of α-synuclein (α-syn) fibrils in Lewy bodies and Lewy neurites is the pathological hallmark of Parkinson disease (PD). Ligands that bind α-syn fibrils could be utilized as imaging agents to improve the diagnosis of PD and to monitor disease progression. However, ligands for α-syn fibri...

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Detalles Bibliográficos
Autores principales: Bagchi, Devika P., Yu, Lihai, Perlmutter, Joel S., Xu, Jinbin, Mach, Robert H., Tu, Zhude, Kotzbauer, Paul T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566091/
https://www.ncbi.nlm.nih.gov/pubmed/23405108
http://dx.doi.org/10.1371/journal.pone.0055031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566091/
https://www.ncbi.nlm.nih.gov/pubmed/23405108
http://dx.doi.org/10.1371/journal.pone.0055031

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