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HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients

BACKGROUND: Highly active antiretroviral therapy (HAART) has significantly decreased mortality among Chinese HIV patients. However, emerging HIV drug resistance (HIVDR) poses a growing threat to the long-term success and durability of HAART. METHODS: Three cross-sectional surveys were conducted acro...

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Autores principales: Xing, Hui, Ruan, Yuhua, Li, Jingyun, Shang, Hong, Zhong, Ping, Wang, Xia, Liao, Lingjie, Li, Hanping, Zhang, Min, Xue, Yile, Wang, Zhe, Su, Bin, Liu, Wei, Dong, Yonghui, Ma, Yanling, Li, Huiqin, Qin, Guangming, Chen, Lin, Pan, Xiaohong, Chen, Xi, Peng, Guoping, Fu, Jihua, Chen, Ray Y., Kang, Laiyi, Shao, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566114/
https://www.ncbi.nlm.nih.gov/pubmed/23405098
http://dx.doi.org/10.1371/journal.pone.0054917
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author Xing, Hui
Ruan, Yuhua
Li, Jingyun
Shang, Hong
Zhong, Ping
Wang, Xia
Liao, Lingjie
Li, Hanping
Zhang, Min
Xue, Yile
Wang, Zhe
Su, Bin
Liu, Wei
Dong, Yonghui
Ma, Yanling
Li, Huiqin
Qin, Guangming
Chen, Lin
Pan, Xiaohong
Chen, Xi
Peng, Guoping
Fu, Jihua
Chen, Ray Y.
Kang, Laiyi
Shao, Yiming
author_facet Xing, Hui
Ruan, Yuhua
Li, Jingyun
Shang, Hong
Zhong, Ping
Wang, Xia
Liao, Lingjie
Li, Hanping
Zhang, Min
Xue, Yile
Wang, Zhe
Su, Bin
Liu, Wei
Dong, Yonghui
Ma, Yanling
Li, Huiqin
Qin, Guangming
Chen, Lin
Pan, Xiaohong
Chen, Xi
Peng, Guoping
Fu, Jihua
Chen, Ray Y.
Kang, Laiyi
Shao, Yiming
author_sort Xing, Hui
collection PubMed
description BACKGROUND: Highly active antiretroviral therapy (HAART) has significantly decreased mortality among Chinese HIV patients. However, emerging HIV drug resistance (HIVDR) poses a growing threat to the long-term success and durability of HAART. METHODS: Three cross-sectional surveys were conducted across the country from 2004 to 2006, respectively. Patients completed a questionnaire and provided blood for CD4 cell count, HIV viral load (VL), and HIV resistance genotyping. Factors associated with HIVDR were identified by logistic regression. RESULTS: 3667 unique patients were included across the three surveys. Among 2826 treatment-experienced patients, median duration of treatment was 17.4 (IQR 8.6–28.4) months and HIVDR was identified in 543 (19.2%). Factors significantly associated with HIVDR included ART drug distribution location, CD4 cell count, initial HAART regimen, self-reported medication adherence, and province. CONCLUSIONS: Virologic failure increased over time on therapy but a significant proportion of patients in failure had no resistance mutations identified, suggesting that treatment adherence is suboptimal and must be emphasized. Due to the significantly higher risk of HIVDR in certain provinces, additional steps to reduce HIVDR should be taken.
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spelling pubmed-35661142013-02-12 HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients Xing, Hui Ruan, Yuhua Li, Jingyun Shang, Hong Zhong, Ping Wang, Xia Liao, Lingjie Li, Hanping Zhang, Min Xue, Yile Wang, Zhe Su, Bin Liu, Wei Dong, Yonghui Ma, Yanling Li, Huiqin Qin, Guangming Chen, Lin Pan, Xiaohong Chen, Xi Peng, Guoping Fu, Jihua Chen, Ray Y. Kang, Laiyi Shao, Yiming PLoS One Research Article BACKGROUND: Highly active antiretroviral therapy (HAART) has significantly decreased mortality among Chinese HIV patients. However, emerging HIV drug resistance (HIVDR) poses a growing threat to the long-term success and durability of HAART. METHODS: Three cross-sectional surveys were conducted across the country from 2004 to 2006, respectively. Patients completed a questionnaire and provided blood for CD4 cell count, HIV viral load (VL), and HIV resistance genotyping. Factors associated with HIVDR were identified by logistic regression. RESULTS: 3667 unique patients were included across the three surveys. Among 2826 treatment-experienced patients, median duration of treatment was 17.4 (IQR 8.6–28.4) months and HIVDR was identified in 543 (19.2%). Factors significantly associated with HIVDR included ART drug distribution location, CD4 cell count, initial HAART regimen, self-reported medication adherence, and province. CONCLUSIONS: Virologic failure increased over time on therapy but a significant proportion of patients in failure had no resistance mutations identified, suggesting that treatment adherence is suboptimal and must be emphasized. Due to the significantly higher risk of HIVDR in certain provinces, additional steps to reduce HIVDR should be taken. Public Library of Science 2013-02-06 /pmc/articles/PMC3566114/ /pubmed/23405098 http://dx.doi.org/10.1371/journal.pone.0054917 Text en © 2013 Xing et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Xing, Hui
Ruan, Yuhua
Li, Jingyun
Shang, Hong
Zhong, Ping
Wang, Xia
Liao, Lingjie
Li, Hanping
Zhang, Min
Xue, Yile
Wang, Zhe
Su, Bin
Liu, Wei
Dong, Yonghui
Ma, Yanling
Li, Huiqin
Qin, Guangming
Chen, Lin
Pan, Xiaohong
Chen, Xi
Peng, Guoping
Fu, Jihua
Chen, Ray Y.
Kang, Laiyi
Shao, Yiming
HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients
title HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients
title_full HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients
title_fullStr HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients
title_full_unstemmed HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients
title_short HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients
title_sort hiv drug resistance and its impact on antiretroviral therapy in chinese hiv-infected patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566114/
https://www.ncbi.nlm.nih.gov/pubmed/23405098
http://dx.doi.org/10.1371/journal.pone.0054917
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