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Dissecting the Gene Dose-Effects of the APOE ε4 and ε2 Alleles on Hippocampal Volumes in Aging and Alzheimer’s Disease

OBJECTIVE: To investigate whether there is a specific dose-dependent effect of the Apolipoprotein E (APOE) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to Alzheimer’s Disease (AD). MATERIALS AND METHODS: We analyzed MR and genetic data on 662 patients fro...

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Detalles Bibliográficos
Autores principales:	Hostage, Christopher A., Roy Choudhury, Kingshuk, Doraiswamy, Pudugramam Murali, Petrella, Jeffrey R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566140/ https://www.ncbi.nlm.nih.gov/pubmed/23405083 http://dx.doi.org/10.1371/journal.pone.0054483

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