Mixed Modeling of Meta-Analysis P-Values (MixMAP) Suggests Multiple Novel Gene Loci for Low Density Lipoprotein Cholesterol

Informing missing heritability for complex disease will likely require leveraging information across multiple SNPs within a gene region simultaneously to characterize gene and locus-level contributions to disease phenotypes. To this aim, we introduce a novel strategy, termed Mixed modeling of Meta-A...

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Detalles Bibliográficos
Autores principales: Foulkes, Andrea S., Matthews, Gregory J., Das, Ujjwal, Ferguson, Jane F., Lin, Rongheng, Reilly, Muredach P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566142/
https://www.ncbi.nlm.nih.gov/pubmed/23405096
http://dx.doi.org/10.1371/journal.pone.0054812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566142/
https://www.ncbi.nlm.nih.gov/pubmed/23405096
http://dx.doi.org/10.1371/journal.pone.0054812

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