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Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men
OBJECTIVE: We assessed changes in sexual behavior among men who have sex with men (MSM), before and for several years after HIV diagnosis, accounting for adoption of a variety of seroadaptive practices. METHODS: We collected self-reported sexual behavior data every 3 months from HIV-positive MSM at...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566177/ https://www.ncbi.nlm.nih.gov/pubmed/23405145 http://dx.doi.org/10.1371/journal.pone.0055397 |
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author | Vallabhaneni, Snigdha McConnell, J. Jeff Loeb, Lisa Hartogensis, Wendy Hecht, Fredrick M. Grant, Robert M. Pilcher, Christopher D. |
author_facet | Vallabhaneni, Snigdha McConnell, J. Jeff Loeb, Lisa Hartogensis, Wendy Hecht, Fredrick M. Grant, Robert M. Pilcher, Christopher D. |
author_sort | Vallabhaneni, Snigdha |
collection | PubMed |
description | OBJECTIVE: We assessed changes in sexual behavior among men who have sex with men (MSM), before and for several years after HIV diagnosis, accounting for adoption of a variety of seroadaptive practices. METHODS: We collected self-reported sexual behavior data every 3 months from HIV-positive MSM at various stages of HIV infection. To establish population level trends in sexual behavior, we used negative binomial regression to model the relationship between time since diagnosis and several sexual behavior variables: numbers of (a) total partners, (b) potentially discordant partners (PDP; i.e., HIV-negative or unknown-status partners), (c) PDPs with whom unprotected anal intercourse (UAI) occurred, and (d) PDPs with whom unprotected insertive anal intercourse (uIAI) occurred. RESULTS: A total of 237 HIV-positive MSM contributed 502 interviews. UAI with PDPs occurred with a mean of 4.2 partners in the 3 months before diagnosis. This declined to 0.9 partners/3 months at 12 months after diagnosis, and subsequently rose to 1.7 partners/3 months at 48 months, before falling again to 1.0 partners/3 months at 60 months. The number of PDPs with whom uIAI occurred dropped from 2.4 in the pre-diagnosis period to 0.3 partners/3 months (an 87.5% reduction) by 12 months after enrollment, and continued to decline over time. CONCLUSION: Within months after being diagnosed with HIV, MSM adopted seroadaptive practices, especially seropositioning, where the HIV-positive partner was not in the insertive position during UAI, resulting in a sustained decline in the sexual activity associated with the highest risk of HIV transmission. |
format | Online Article Text |
id | pubmed-3566177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35661772013-02-12 Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men Vallabhaneni, Snigdha McConnell, J. Jeff Loeb, Lisa Hartogensis, Wendy Hecht, Fredrick M. Grant, Robert M. Pilcher, Christopher D. PLoS One Research Article OBJECTIVE: We assessed changes in sexual behavior among men who have sex with men (MSM), before and for several years after HIV diagnosis, accounting for adoption of a variety of seroadaptive practices. METHODS: We collected self-reported sexual behavior data every 3 months from HIV-positive MSM at various stages of HIV infection. To establish population level trends in sexual behavior, we used negative binomial regression to model the relationship between time since diagnosis and several sexual behavior variables: numbers of (a) total partners, (b) potentially discordant partners (PDP; i.e., HIV-negative or unknown-status partners), (c) PDPs with whom unprotected anal intercourse (UAI) occurred, and (d) PDPs with whom unprotected insertive anal intercourse (uIAI) occurred. RESULTS: A total of 237 HIV-positive MSM contributed 502 interviews. UAI with PDPs occurred with a mean of 4.2 partners in the 3 months before diagnosis. This declined to 0.9 partners/3 months at 12 months after diagnosis, and subsequently rose to 1.7 partners/3 months at 48 months, before falling again to 1.0 partners/3 months at 60 months. The number of PDPs with whom uIAI occurred dropped from 2.4 in the pre-diagnosis period to 0.3 partners/3 months (an 87.5% reduction) by 12 months after enrollment, and continued to decline over time. CONCLUSION: Within months after being diagnosed with HIV, MSM adopted seroadaptive practices, especially seropositioning, where the HIV-positive partner was not in the insertive position during UAI, resulting in a sustained decline in the sexual activity associated with the highest risk of HIV transmission. Public Library of Science 2013-02-06 /pmc/articles/PMC3566177/ /pubmed/23405145 http://dx.doi.org/10.1371/journal.pone.0055397 Text en © 2013 Vallabhaneni et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Vallabhaneni, Snigdha McConnell, J. Jeff Loeb, Lisa Hartogensis, Wendy Hecht, Fredrick M. Grant, Robert M. Pilcher, Christopher D. Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men |
title | Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men |
title_full | Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men |
title_fullStr | Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men |
title_full_unstemmed | Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men |
title_short | Changes in Seroadaptive Practices from before to after Diagnosis of Recent HIV Infection among Men Who Have Sex with Men |
title_sort | changes in seroadaptive practices from before to after diagnosis of recent hiv infection among men who have sex with men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566177/ https://www.ncbi.nlm.nih.gov/pubmed/23405145 http://dx.doi.org/10.1371/journal.pone.0055397 |
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