Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells and keratinocytes in aged human skin in vivo

The dermal extracellular matrix (ECM) provides strength and resiliency to skin. The ECM consists mostly of type I collagen fibrils, which are produced by fibroblasts. Binding of fibroblasts to collagen fibrils generates mechanical forces, which regulate cellular morphology and function. With aging,...

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Detalles Bibliográficos
Autores principales: Quan, Taihao, Wang, Frank, Shao, Yuan, Rittié, Laure, Xia, Wei, Orringer, Jeffrey S., Voorhees, John J., Fisher, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566280/
https://www.ncbi.nlm.nih.gov/pubmed/23096713
http://dx.doi.org/10.1038/jid.2012.364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566280/
https://www.ncbi.nlm.nih.gov/pubmed/23096713
http://dx.doi.org/10.1038/jid.2012.364

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