Prediction of Functional Loss of Human Angiogenin Mutants Associated with ALS by Molecular Dynamics Simulations

Several missense mutations in the coding region of angiogenin (ANG) gene have been identified in Amyotrophic Lateral Sclerosis (ALS) patients. These mutations lead to loss of either ribonucleolytic activity or nuclear translocation activity or both of ANG (protein encoded by ANG gene) causing ALS. W...

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Detalles Bibliográficos
Autores principales: Padhi, Aditya K., Jayaram, Bhyravabhotla, Gomes, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566597/
https://www.ncbi.nlm.nih.gov/pubmed/23393617
http://dx.doi.org/10.1038/srep01225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566597/
https://www.ncbi.nlm.nih.gov/pubmed/23393617
http://dx.doi.org/10.1038/srep01225

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