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Metal-mediated aminocatalysis provides mild conditions: Enantioselective Michael addition mediated by primary amino catalysts and alkali-metal ions

Four catalysts based on new amides of chiral 1,2-diamines and 2-sulfobenzoic acid have been developed. The alkali-metal salts of these betaine-like amides are able to form imines with enones, which are activated by Lewis acid interaction for nucleophilic attack by 4-hydroxycoumarin. The addition of...

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Detalles Bibliográficos
Autores principales:	Leven, Matthias, Neudörfl, Jörg M, Goldfuss, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2013
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566766/ https://www.ncbi.nlm.nih.gov/pubmed/23400419 http://dx.doi.org/10.3762/bjoc.9.18

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