A new synthetic protocol for coumarin amino acid

The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of...

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Detalles Bibliográficos
Autores principales: Xu, Xinyi, Hu, Xiaosong, Wang, Jiangyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566773/
https://www.ncbi.nlm.nih.gov/pubmed/23400513
http://dx.doi.org/10.3762/bjoc.9.30
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author Xu, Xinyi
Hu, Xiaosong
Wang, Jiangyun
author_facet Xu, Xinyi
Hu, Xiaosong
Wang, Jiangyun
author_sort Xu, Xinyi
collection PubMed
description The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of fluorescent amino acid with the new synthetic method. Furthermore, it can be applied to synthesize other derivatives of the coumarin amino acid with some specific properties.
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spelling pubmed-35667732013-02-11 A new synthetic protocol for coumarin amino acid Xu, Xinyi Hu, Xiaosong Wang, Jiangyun Beilstein J Org Chem Full Research Paper The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps. It is less costly and relatively easy to prepare this kind of fluorescent amino acid with the new synthetic method. Furthermore, it can be applied to synthesize other derivatives of the coumarin amino acid with some specific properties. Beilstein-Institut 2013-02-06 /pmc/articles/PMC3566773/ /pubmed/23400513 http://dx.doi.org/10.3762/bjoc.9.30 Text en Copyright © 2013, Xu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Xu, Xinyi
Hu, Xiaosong
Wang, Jiangyun
A new synthetic protocol for coumarin amino acid
title A new synthetic protocol for coumarin amino acid
title_full A new synthetic protocol for coumarin amino acid
title_fullStr A new synthetic protocol for coumarin amino acid
title_full_unstemmed A new synthetic protocol for coumarin amino acid
title_short A new synthetic protocol for coumarin amino acid
title_sort new synthetic protocol for coumarin amino acid
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566773/
https://www.ncbi.nlm.nih.gov/pubmed/23400513
http://dx.doi.org/10.3762/bjoc.9.30
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