Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo

BACKGROUND: Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5′-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS: The expres...

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Detalles Bibliográficos
Autores principales: Duivenvoorden, W C, Beatty, L K, Lhotak, S, Hill, B, Mak, I, Paulin, G, Gallino, D, Popovic, S, Austin, R C, Pinthus, J H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566816/
https://www.ncbi.nlm.nih.gov/pubmed/23322200
http://dx.doi.org/10.1038/bjc.2012.574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566816/
https://www.ncbi.nlm.nih.gov/pubmed/23322200
http://dx.doi.org/10.1038/bjc.2012.574

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