Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker

Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficien...

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Detalles Bibliográficos
Autores principales: Collot, Mayeul, Eller, Steffen, Weishaupt, Markus, Seeberger, Peter H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566856/
https://www.ncbi.nlm.nih.gov/pubmed/23400514
http://dx.doi.org/10.3762/bjoc.9.13
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author Collot, Mayeul
Eller, Steffen
Weishaupt, Markus
Seeberger, Peter H
author_facet Collot, Mayeul
Eller, Steffen
Weishaupt, Markus
Seeberger, Peter H
author_sort Collot, Mayeul
collection PubMed
description Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found.
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spelling pubmed-35668562013-02-11 Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker Collot, Mayeul Eller, Steffen Weishaupt, Markus Seeberger, Peter H Beilstein J Org Chem Letter Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found. Beilstein-Institut 2013-01-16 /pmc/articles/PMC3566856/ /pubmed/23400514 http://dx.doi.org/10.3762/bjoc.9.13 Text en Copyright © 2013, Collot et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Collot, Mayeul
Eller, Steffen
Weishaupt, Markus
Seeberger, Peter H
Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
title Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
title_full Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
title_fullStr Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
title_full_unstemmed Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
title_short Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
title_sort glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566856/
https://www.ncbi.nlm.nih.gov/pubmed/23400514
http://dx.doi.org/10.3762/bjoc.9.13
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AT weishauptmarkus glycosylationefficienciesondifferentsolidsupportsusingahydrogenolysislabilelinker
AT seebergerpeterh glycosylationefficienciesondifferentsolidsupportsusingahydrogenolysislabilelinker

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