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The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

Aiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP (diketopiperazine)-based peptidomimetic scaffold capable of arranging in an unusual α-turn conformation. The synthesis is based on a diastereoselective Pictet–Sp...

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Detalles Bibliográficos
Autores principales:	Airaghi, Francesco, Fiorati, Andrea, Lesma, Giordano, Musolino, Manuele, Sacchetti, Alessandro, Silvani, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2013
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566863/ https://www.ncbi.nlm.nih.gov/pubmed/23399789 http://dx.doi.org/10.3762/bjoc.9.17

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