Chronic Over-Expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: A Combined Histological and Mechanical Assessment of Aortic Lesions

AIMS: Expression of Heat Shock Protein-27 (HSP27) is reduced in human coronary atherosclerosis. Over-expression of HSP27 is protective against the early formation of lesions in atherosclerosis-prone apoE(−/−) mice (apoE(−/−)HSP27(o/e)) - however, only in females. We now seek to determine if chronic...

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Detalles Bibliográficos
Autores principales: Cuerrier, Charles M., Chen, Yong-Xiang, Tremblay, Dominique, Rayner, Katey, McNulty, Melissa, Zhao, XiaoLing, Kennedy, Christopher R. J., de BelleRoche, Jacqueline, Pelling, Andrew E., O'Brien, Edward R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567023/
https://www.ncbi.nlm.nih.gov/pubmed/23409070
http://dx.doi.org/10.1371/journal.pone.0055867

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