miR-221/222 Compensates for Skp2-Mediated p27 Degradation and Is a Primary Target of Cell Cycle Regulation by Prostacyclin and cAMP

p27(kip1) (p27) is a cdk-inhibitory protein with an important role in the proliferation of many cell types. SCF(Skp2) is the best studied regulator of p27 levels, but Skp2-mediated p27 degradation is not essential in vivo or in vitro. The molecular pathway that compensates for loss of Skp2-mediated...

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Detalles Bibliográficos
Autores principales: Castagnino, Paola, Kothapalli, Devashish, Hawthorne, Elizabeth A., Liu, Shu-Lin, Xu, Tina, Rao, Shilpa, Yung, Yuval, Assoian, Richard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567044/
https://www.ncbi.nlm.nih.gov/pubmed/23409140
http://dx.doi.org/10.1371/journal.pone.0056140

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