Molecular Mechanisms Underlying the Analgesic Property of Intrathecal Dexmedetomidine and Its Neurotoxicity Evaluation: An In Vivo and In Vitro Experimental Study

BACKGROUND: Dexmedetomidine (DEX) has been used under perioperative settings as an adjuvant to enhance the analgesic property of local anesthetics by some anesthesiologists. However, the analgesic mechanisms and neurotoxicity of DEX were poorly understood. This study examined the effect of DEX alone...

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Detalles Bibliográficos
Autores principales: Zhang, Hongxing, Zhou, Fang, Li, Chen, Kong, Min, Liu, He, Zhang, Peng, Zhang, Song, Cao, Junli, Zhang, Licai, Ma, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567091/
https://www.ncbi.nlm.nih.gov/pubmed/23409000
http://dx.doi.org/10.1371/journal.pone.0055556

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