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dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. We previously showed that the expression of dynactin 1, an axon motor protein regulating retrograde transport, is markedly reduced in spinal motor neurons of sporadic ALS...

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Detalles Bibliográficos
Autores principales:	Ikenaka, Kensuke, Kawai, Kaori, Katsuno, Masahisa, Huang, Zhe, Jiang, Yue-Mei, Iguchi, Yohei, Kobayashi, Kyogo, Kimata, Tsubasa, Waza, Masahiro, Tanaka, Fumiaki, Mori, Ikue, Sobue, Gen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567092/ https://www.ncbi.nlm.nih.gov/pubmed/23408943 http://dx.doi.org/10.1371/journal.pone.0054511

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