Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

BACKGROUND: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded contradictory findings on the role of hypercoagula...

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Detalles Bibliográficos
Autores principales: Borissoff, Julian I., Otten, Jeroen J. T., Heeneman, Sylvia, Leenders, Peter, van Oerle, René, Soehnlein, Oliver, Loubele, Sarah T. B. G., Hamulyák, Karly, Hackeng, Tilman M., Daemen, Mat J. A. P., Degen, Jay L., Weiler, Hartmut, Esmon, Charles T., van Ryn, Joanne, Biessen, Erik A. L., Spronk, Henri M. H., ten Cate, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567111/
https://www.ncbi.nlm.nih.gov/pubmed/23409043
http://dx.doi.org/10.1371/journal.pone.0055784

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