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Acquisition of Drug Resistance and Dependence by Prions
We have reported that properties of prion strains may change when propagated in different environments. For example, when swainsonine-sensitive 22L prions were propagated in PK1 cells in the presence of swainsonine, drug-resistant variants emerged. We proposed that prions constitute quasi- populatio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567182/ https://www.ncbi.nlm.nih.gov/pubmed/23408888 http://dx.doi.org/10.1371/journal.ppat.1003158 |