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The skin function: a factor of anti-metabolic syndrome
The body’s total antioxidant capacity represents a sum of the antioxidant capacity of various tissues/organs. A decrease in the body’s antioxidant capacity may induce oxidative stress and subsequent metabolic syndrome, a clustering of risk factors for type 2 diabetes and cardiovascular disease. The...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567429/ https://www.ncbi.nlm.nih.gov/pubmed/22537765 http://dx.doi.org/10.1186/1758-5996-4-15 |
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author | Zhou, Shi-Sheng Li, Da Zhou, Yi-Ming Cao, Ji-Min |
author_facet | Zhou, Shi-Sheng Li, Da Zhou, Yi-Ming Cao, Ji-Min |
author_sort | Zhou, Shi-Sheng |
collection | PubMed |
description | The body’s total antioxidant capacity represents a sum of the antioxidant capacity of various tissues/organs. A decrease in the body’s antioxidant capacity may induce oxidative stress and subsequent metabolic syndrome, a clustering of risk factors for type 2 diabetes and cardiovascular disease. The skin, the largest organ of the body, is one of the major components of the body’s total antioxidant defense system, primarily through its xenobiotic/drug biotransformation system, reactive oxygen species-scavenging system, and sweat glands- and sebaceous glands-mediated excretion system. Notably, unlike other contributors, the skin contribution is variable, depending on lifestyles and ambient temperature or seasonal variations. Emerging evidence suggests that decreased skin’s antioxidant and excretory functions (e.g., due to sedentary lifestyles and low ambient temperature) may increase the risk for metabolic syndrome. This review focuses on the relationship between the variability of skin-mediated detoxification and elimination of exogenous and endogenous toxic substances and the development of metabolic syndrome. The potential role of sebum secretion in lipid and cholesterol homeostasis and its impact on metabolic syndrome, and the association between skin disorders (acanthosis nigricans, acne, and burn) and metabolic syndrome are also discussed. |
format | Online Article Text |
id | pubmed-3567429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35674292013-02-08 The skin function: a factor of anti-metabolic syndrome Zhou, Shi-Sheng Li, Da Zhou, Yi-Ming Cao, Ji-Min Diabetol Metab Syndr Review The body’s total antioxidant capacity represents a sum of the antioxidant capacity of various tissues/organs. A decrease in the body’s antioxidant capacity may induce oxidative stress and subsequent metabolic syndrome, a clustering of risk factors for type 2 diabetes and cardiovascular disease. The skin, the largest organ of the body, is one of the major components of the body’s total antioxidant defense system, primarily through its xenobiotic/drug biotransformation system, reactive oxygen species-scavenging system, and sweat glands- and sebaceous glands-mediated excretion system. Notably, unlike other contributors, the skin contribution is variable, depending on lifestyles and ambient temperature or seasonal variations. Emerging evidence suggests that decreased skin’s antioxidant and excretory functions (e.g., due to sedentary lifestyles and low ambient temperature) may increase the risk for metabolic syndrome. This review focuses on the relationship between the variability of skin-mediated detoxification and elimination of exogenous and endogenous toxic substances and the development of metabolic syndrome. The potential role of sebum secretion in lipid and cholesterol homeostasis and its impact on metabolic syndrome, and the association between skin disorders (acanthosis nigricans, acne, and burn) and metabolic syndrome are also discussed. BioMed Central 2012-04-26 /pmc/articles/PMC3567429/ /pubmed/22537765 http://dx.doi.org/10.1186/1758-5996-4-15 Text en Copyright ©2012 Zhou et al.; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Zhou, Shi-Sheng Li, Da Zhou, Yi-Ming Cao, Ji-Min The skin function: a factor of anti-metabolic syndrome |
title | The skin function: a factor of anti-metabolic syndrome |
title_full | The skin function: a factor of anti-metabolic syndrome |
title_fullStr | The skin function: a factor of anti-metabolic syndrome |
title_full_unstemmed | The skin function: a factor of anti-metabolic syndrome |
title_short | The skin function: a factor of anti-metabolic syndrome |
title_sort | skin function: a factor of anti-metabolic syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567429/ https://www.ncbi.nlm.nih.gov/pubmed/22537765 http://dx.doi.org/10.1186/1758-5996-4-15 |
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