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Modelling the evolution of genetic instability during tumour progression

The role of genetic instability in driving carcinogenesis remains controversial. Genetic instability should accelerate carcinogenesis by increasing the rate of advantageous driver mutations; however, genetic instability can also potentially retard tumour growth by increasing the rate of deleterious...

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Detalles Bibliográficos
Autores principales:	S Datta, Ruchira, Gutteridge, Alice, Swanton, Charles, Maley, Carlo C, Graham, Trevor A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567468/ https://www.ncbi.nlm.nih.gov/pubmed/23396531 http://dx.doi.org/10.1111/eva.12024

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