Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload

Integrins are adhesive, signaling, and mechanotransduction proteins. Talin (Tln) activates integrins and links it to the actin cytoskeleton. Vertebrates contain two talin genes, tln1 and tln2. How Tln1 and Tln2 function in cardiac myocytes (CMs) is unknown. Tln1 and Tln2 expression were evaluated in...

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Detalles Bibliográficos
Autores principales: Manso, Ana Maria, Li, Ruixia, Monkley, Susan J., Cruz, Nathalia M., Ong, Shannon, Lao, Dieu H., Koshman, Yevgeniya E., Gu, Yusu, Peterson, Kirk L., Chen, Ju, Abel, E. Dale, Samarel, Allen M., Critchley, David R., Ross, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567677/
https://www.ncbi.nlm.nih.gov/pubmed/23266827
http://dx.doi.org/10.1074/jbc.M112.427484

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