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High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth
We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 µm in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567712/ https://www.ncbi.nlm.nih.gov/pubmed/23411636 http://dx.doi.org/10.1364/BOE.4.000245 |
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author | An, Lin Li, Peng Lan, Gongpu Malchow, Doug Wang, Ruikang K. |
author_facet | An, Lin Li, Peng Lan, Gongpu Malchow, Doug Wang, Ruikang K. |
author_sort | An, Lin |
collection | PubMed |
description | We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 µm in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an imaging speed of 120,000 A-scans per second. We experimentally demonstrate the system’s capability to perform phase-resolved imaging of dynamic blood flow within retina, indicating high phase stability of the SDOCT system. Finally, we show an example that uses this newly developed system to image posterior segment of human eye with a large view of view (10 × 9 mm(2)), providing detailed visualization of microstructural features from anterior retina to posterior choroid. The demonstrated system parameters and imaging performances are comparable to those that a typical 1 µm swept source OCT would deliver for retinal imaging. |
format | Online Article Text |
id | pubmed-3567712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-35677122013-02-14 High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth An, Lin Li, Peng Lan, Gongpu Malchow, Doug Wang, Ruikang K. Biomed Opt Express Optical Coherence Tomography We report a newly developed high speed 1050nm spectral domain optical coherence tomography (SD-OCT) system for imaging posterior segment of human eye. The system is capable of an axial resolution at ~10 µm in air, an imaging depth of 6.1 mm in air, a system sensitivity fall-off at ~6 dB/3mm and an imaging speed of 120,000 A-scans per second. We experimentally demonstrate the system’s capability to perform phase-resolved imaging of dynamic blood flow within retina, indicating high phase stability of the SDOCT system. Finally, we show an example that uses this newly developed system to image posterior segment of human eye with a large view of view (10 × 9 mm(2)), providing detailed visualization of microstructural features from anterior retina to posterior choroid. The demonstrated system parameters and imaging performances are comparable to those that a typical 1 µm swept source OCT would deliver for retinal imaging. Optical Society of America 2013-01-16 /pmc/articles/PMC3567712/ /pubmed/23411636 http://dx.doi.org/10.1364/BOE.4.000245 Text en ©2013 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Optical Coherence Tomography An, Lin Li, Peng Lan, Gongpu Malchow, Doug Wang, Ruikang K. High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth |
title | High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120
kHz A-scan rate with 6.1 mm imaging depth |
title_full | High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120
kHz A-scan rate with 6.1 mm imaging depth |
title_fullStr | High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120
kHz A-scan rate with 6.1 mm imaging depth |
title_full_unstemmed | High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120
kHz A-scan rate with 6.1 mm imaging depth |
title_short | High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120
kHz A-scan rate with 6.1 mm imaging depth |
title_sort | high-resolution 1050 nm spectral domain retinal optical coherence tomography at 120
khz a-scan rate with 6.1 mm imaging depth |
topic | Optical Coherence Tomography |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567712/ https://www.ncbi.nlm.nih.gov/pubmed/23411636 http://dx.doi.org/10.1364/BOE.4.000245 |
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