Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A(2A) receptor-dependent manner: A(2A) receptor blockade prevents BDNF release and proliferation of microglia

BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been shown to control microglial responses in neuropathic pain. Since adenosine A(2A) receptors (A(2A)Rs) control neuroinflammation, as well as the production and function of BDNF, we tested to see if A(2A)R controls the microglia-dependent se...

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Detalles Bibliográficos
Autores principales: Gomes, Catarina, Ferreira, Raquel, George, Jimmy, Sanches, Rui, Rodrigues, Diana I, Gonçalves, Nélio, Cunha, Rodrigo A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567964/
https://www.ncbi.nlm.nih.gov/pubmed/23363775
http://dx.doi.org/10.1186/1742-2094-10-16

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