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Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells

BACKGROUND: During metaphase clathrin stabilises the mitotic spindle kinetochore(K)-fibres. Many anti-mitotic compounds target microtubule dynamics. Pitstop 2™ is the first small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis. We investigated its effects on...

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Detalles Bibliográficos
Autores principales:	Smith, Charlotte M, Haucke, Volker, McCluskey, Adam, Robinson, Phillip J, Chircop, Megan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567983/ https://www.ncbi.nlm.nih.gov/pubmed/23327284 http://dx.doi.org/10.1186/1476-4598-12-4

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