Genetics of scleroderma: implications for personalized medicine?

Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to vario...

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Autores principales: Assassi, Shervin, Radstake, Timothy RDJ, Mayes, Maureen D, Martin, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568008/
https://www.ncbi.nlm.nih.gov/pubmed/23311619
http://dx.doi.org/10.1186/1741-7015-11-9
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author Assassi, Shervin
Radstake, Timothy RDJ
Mayes, Maureen D
Martin, Javier
author_facet Assassi, Shervin
Radstake, Timothy RDJ
Mayes, Maureen D
Martin, Javier
author_sort Assassi, Shervin
collection PubMed
description Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to various systemic sclerosis disease manifestations. Furthermore, inclusion of genetic studies in design and analysis of drug trials could lead to development of genetic biomarkers that predict treatment response. Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis.
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spelling pubmed-35680082013-02-13 Genetics of scleroderma: implications for personalized medicine? Assassi, Shervin Radstake, Timothy RDJ Mayes, Maureen D Martin, Javier BMC Med Minireview Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment? Besides robustly replicated genetic susceptibility loci, several genes have been recently linked to various systemic sclerosis disease manifestations. Furthermore, inclusion of genetic studies in design and analysis of drug trials could lead to development of genetic biomarkers that predict treatment response. Future genetic studies in well-characterized systemic sclerosis cohorts paired with advanced analytic approaches can lead to development of genetic biomarkers for targeted diagnostic and therapeutic interventions in systemic sclerosis. BioMed Central 2013-01-11 /pmc/articles/PMC3568008/ /pubmed/23311619 http://dx.doi.org/10.1186/1741-7015-11-9 Text en Copyright ©2013 Assassi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Assassi, Shervin
Radstake, Timothy RDJ
Mayes, Maureen D
Martin, Javier
Genetics of scleroderma: implications for personalized medicine?
title Genetics of scleroderma: implications for personalized medicine?
title_full Genetics of scleroderma: implications for personalized medicine?
title_fullStr Genetics of scleroderma: implications for personalized medicine?
title_full_unstemmed Genetics of scleroderma: implications for personalized medicine?
title_short Genetics of scleroderma: implications for personalized medicine?
title_sort genetics of scleroderma: implications for personalized medicine?
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568008/
https://www.ncbi.nlm.nih.gov/pubmed/23311619
http://dx.doi.org/10.1186/1741-7015-11-9
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