Cargando…

MtrR Control of a Transcriptional Regulatory Pathway in Neisseria meningitidis That Influences Expression of a Gene (nadA) Encoding a Vaccine Candidate

The surface-exposed NadA adhesin produced by a subset of capsular serogroup B strains of Neisseria meningitidis is currently being considered as a vaccine candidate to prevent invasive disease caused by a hypervirulent lineage of meningococci. Levels of NadA are known to be controlled by both transc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cloward, Jason M., Shafer, William M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568044/ https://www.ncbi.nlm.nih.gov/pubmed/23409129 http://dx.doi.org/10.1371/journal.pone.0056097

Ejemplares similares

NadA, a Novel Vaccine Candidate of Neisseria meningitidis
por: Comanducci, Maurizio, et al.
Publicado: (2002)

Dueling Regulatory Properties of a Transcriptional Activator (MtrA) and Repressor (MtrR) That Control Efflux Pump Gene Expression in Neisseria gonorrhoeae
por: Zalucki, Yaramah M., et al.
Publicado: (2012)

In silico Homology Modeling and Epitope Prediction of NadA as a Potential Vaccine Candidate in Neisseria meningitidis
por: Shahsavani, Narjes, et al.
Publicado: (2018)

The Transcriptional Repressor, MtrR, of the mtrCDE Efflux Pump Operon of Neisseria gonorrhoeae Can Also Serve as an Activator of “off Target” Gene (glnE) Expression
por: Johnson, Paul J. T., et al.
Publicado: (2015)

Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae
por: Beggs, Grace A., et al.
Publicado: (2019)

Control of gdhR Expression in Neisseria gonorrhoeae via Autoregulation and a Master Repressor (MtrR) of a Drug Efflux Pump Operon
por: Rouquette-Loughlin, Corinne E., et al.
Publicado: (2017)

Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations
por: Beggs, Grace A, et al.
Publicado: (2021)

1440. The Genetic Basis for a Neisseria gonorrhoeae Clinical Isolate That Contains mtrR(-79) Mutation But Is Highly Susceptible to Antibiotics Effluxed by the Mtr Pump System
por: Huang, Jianzhong, et al.
Publicado: (2020)

The Soluble Recombinant Neisseria meningitidis Adhesin NadA(Δ351–405) Stimulates Human Monocytes by Binding to Extracellular Hsp90
por: Cecchini, Paola, et al.
Publicado: (2011)

Single Domain Antibodies Targeting Receptor Binding Pockets of NadA Restrain Adhesion of Neisseria meningitidis to Human Brain Microvascular Endothelial Cells
por: Kulkarni, Amod, et al.
Publicado: (2020)

Phase Variation of NadA in Invasive Neisseria meningitidis Isolates Impacts on Coverage Estimates for 4C-MenB, a MenB Vaccine
por: Green, Luke R., et al.
Publicado: (2018)

Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association
por: Wang, Yongxin, et al.
Publicado: (2015)

Analysis of MTR and MTRR Gene Polymorphisms in Chinese Patients With Ventricular Septal Defect
por: Su, Jiang, et al.
Publicado: (2018)

Genetic Variant in MTRR, but Not MTR, Is Associated with Risk of Congenital Heart Disease: An Integrated Meta-Analysis
por: Cai, Bingxi, et al.
Publicado: (2014)

MTR, MTRR and CBS Gene Polymorphisms in Recurrent Miscarriages: A Case Control Study from North India
por: Talwar, Seerat, et al.
Publicado: (2022)

Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility
por: Ren, Zheng-Ju, et al.
Publicado: (2019)

Association of MTR A2756G and MTRR A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis
por: Tariq, Tamjeed, et al.
Publicado: (2023)

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA
por: Liguori, Alessia, et al.
Publicado: (2016)

Evidence that the nadA motif is a bacterial riboswitch for the ubiquitous enzyme cofactor NAD(+)
por: Malkowski, Sarah N., et al.
Publicado: (2019)

Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population
por: Lv, Shuang, et al.
Publicado: (2018)

Could Dampening Expression of the Neisseria gonorrhoeae mtrCDE-Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?
por: Chen, Shaochun, et al.
Publicado: (2019)

Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population
por: Kurzawski, Mateusz, et al.
Publicado: (2015)

Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study
por: Li, Wen-Xing, et al.
Publicado: (2015)

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
por: Bolla, Jani Reddy, et al.
Publicado: (2014)

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel
por: Lei, Hsiang-Ting, et al.
Publicado: (2014)

Neisseria Base: a comparative genomics database for Neisseria meningitidis
por: Katz, Lee S., et al.
Publicado: (2011)

Characterization of a transcriptional TPP riboswitch in the human pathogen Neisseria meningitidis
por: Righetti, Francesco, et al.
Publicado: (2020)

Modulation of the Neisseria gonorrhoeae drug efflux conduit MtrE
por: Tamburrino, Giulia, et al.
Publicado: (2017)

Genealogical typing of Neisseria meningitidis
por: Didelot, Xavier, et al.
Publicado: (2009)

Rifampin-resistant Neisseria meningitidis
por: Taha, Muhamed-Kheir, et al.
Publicado: (2006)

Towards the Immunoproteome of Neisseria meningitidis
por: Mendum, Tom A., et al.
Publicado: (2009)

Metabolism and virulence in Neisseria meningitidis
por: Schoen, Christoph, et al.
Publicado: (2014)

Genome flexibility in Neisseria meningitidis
por: Schoen, Christoph, et al.
Publicado: (2009)

The Hfq regulon of Neisseria meningitidis
por: Huis in ‘t Veld, Robert A. G., et al.
Publicado: (2017)

Gonococcal Clinical Strains Bearing a Common gdhR Single Nucleotide Polymorphism That Results in Enhanced Expression of the Virulence Gene lctP Frequently Possess a mtrR Promoter Mutation That Decreases Antibiotic Susceptibility
por: Ayala, Julio C., et al.
Publicado: (2022)

Are the Genes nadA and norB Involved in Formation of Aflatoxin G(1)?
por: Ehrlich, Kenneth C., et al.
Publicado: (2008)

The comparative population genetics of Neisseria meningitidis and Neisseria gonorrhoeae
por: Vigué, Lucile, et al.
Publicado: (2019)

Protocol for a controlled human infection with genetically modified Neisseria lactamica expressing the meningococcal vaccine antigen NadA: a potent new technique for experimental medicine
por: Gbesemete, Diane, et al.
Publicado: (2019)

PorA Variable Regions of Neisseria meningitidis
por: Russell, Joanne E., et al.
Publicado: (2004)

Genomic Diversity and Chromosomal Rearrangements in Neisseria gonorrhoeae and Neisseria meningitidis
por: Shaskolskiy, Boris, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mfm2pe4thj4s6uftiujp6mgejm