Ozagrel hydrochloride, a selective thromboxane A(2) synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice

BACKGROUND: Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A(2) (TXA(2)) synthase inhibitor, on liver injury induced by APAP overdose in mice. METHODS: Hepatotoxicity was induced to ICR male...

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Detalles Bibliográficos
Autores principales: Tomishima, Yoshiro, Ishitsuka, Yoichi, Matsunaga, Naoya, Nagatome, Minako, Furusho, Hirokazu, Irikura, Mitsuru, Ohdo, Shigehiro, Irie, Tetsumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568068/
https://www.ncbi.nlm.nih.gov/pubmed/23363429
http://dx.doi.org/10.1186/1471-230X-13-21

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