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Size-tunable drug-delivery capsules composed of a magnetic nanoshell

Nano-sized FePt capsules with two types of ultrathin shell were fabricated using a template method for use in a nano-scale drug delivery system. One capsule was composed of an inorganic-organic hybrid shell of a water-soluble polymer and FePt nanoparticles, and the other capsule was composed of a ne...

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Autores principales: Fuchigami, Teruaki, Kitamoto, Yoshitaka, Namiki, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568115/
https://www.ncbi.nlm.nih.gov/pubmed/23507895
http://dx.doi.org/10.4161/biom.22617
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author Fuchigami, Teruaki
Kitamoto, Yoshitaka
Namiki, Yoshihisa
author_facet Fuchigami, Teruaki
Kitamoto, Yoshitaka
Namiki, Yoshihisa
author_sort Fuchigami, Teruaki
collection PubMed
description Nano-sized FePt capsules with two types of ultrathin shell were fabricated using a template method for use in a nano-scale drug delivery system. One capsule was composed of an inorganic-organic hybrid shell of a water-soluble polymer and FePt nanoparticles, and the other capsule was composed of a network of fused FePt nanoparticles. We demonstrated that FePt nanoparticles selectively accumulated on the polymer molecules adsorbed on the template silica particles, and investigated the morphologies of the particle accumulation by changing the concentration of the polymer solution with which the template particles were treated. Capsular size was reduced from 340 to less than 90 nm by changing the size of the silica template particles, and the shell thickness was controlled by changing the amount of FePt nanoparticles adsorbed on the template particles. The hybrid shell was maintained by the connection of FePt nanoparticles and polymer molecules, and the shell thickness was 10 nm at the maximum. The FePt network shell was fabricated by hydrothermal treatment of the FePt/polymer-modified silica composite particles. The FePt network shell was produced from only the FePt alloy, and the shell thickness was 3 nm. Water-soluble anti-cancer drugs could be loaded into the hollow space of FePt network capsules, and lipid-coated FePt network capsules loaded with anti-cancer drugs showed cellular toxicity. The nano-sized capsular structure and the ultrathin shell suggest applicability as a drug carrier in magnetically guided drug delivery systems.
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spelling pubmed-35681152013-05-22 Size-tunable drug-delivery capsules composed of a magnetic nanoshell Fuchigami, Teruaki Kitamoto, Yoshitaka Namiki, Yoshihisa Biomatter Special Focus Report Nano-sized FePt capsules with two types of ultrathin shell were fabricated using a template method for use in a nano-scale drug delivery system. One capsule was composed of an inorganic-organic hybrid shell of a water-soluble polymer and FePt nanoparticles, and the other capsule was composed of a network of fused FePt nanoparticles. We demonstrated that FePt nanoparticles selectively accumulated on the polymer molecules adsorbed on the template silica particles, and investigated the morphologies of the particle accumulation by changing the concentration of the polymer solution with which the template particles were treated. Capsular size was reduced from 340 to less than 90 nm by changing the size of the silica template particles, and the shell thickness was controlled by changing the amount of FePt nanoparticles adsorbed on the template particles. The hybrid shell was maintained by the connection of FePt nanoparticles and polymer molecules, and the shell thickness was 10 nm at the maximum. The FePt network shell was fabricated by hydrothermal treatment of the FePt/polymer-modified silica composite particles. The FePt network shell was produced from only the FePt alloy, and the shell thickness was 3 nm. Water-soluble anti-cancer drugs could be loaded into the hollow space of FePt network capsules, and lipid-coated FePt network capsules loaded with anti-cancer drugs showed cellular toxicity. The nano-sized capsular structure and the ultrathin shell suggest applicability as a drug carrier in magnetically guided drug delivery systems. Landes Bioscience 2012-10-01 2012-10-01 /pmc/articles/PMC3568115/ /pubmed/23507895 http://dx.doi.org/10.4161/biom.22617 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Special Focus Report
Fuchigami, Teruaki
Kitamoto, Yoshitaka
Namiki, Yoshihisa
Size-tunable drug-delivery capsules composed of a magnetic nanoshell
title Size-tunable drug-delivery capsules composed of a magnetic nanoshell
title_full Size-tunable drug-delivery capsules composed of a magnetic nanoshell
title_fullStr Size-tunable drug-delivery capsules composed of a magnetic nanoshell
title_full_unstemmed Size-tunable drug-delivery capsules composed of a magnetic nanoshell
title_short Size-tunable drug-delivery capsules composed of a magnetic nanoshell
title_sort size-tunable drug-delivery capsules composed of a magnetic nanoshell
topic Special Focus Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568115/
https://www.ncbi.nlm.nih.gov/pubmed/23507895
http://dx.doi.org/10.4161/biom.22617
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