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Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections

Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure...

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Autor principal: Morrissey, C. Orla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Science Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568482/
https://www.ncbi.nlm.nih.gov/pubmed/23420637
http://dx.doi.org/10.1007/s12281-012-0128-4
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author Morrissey, C. Orla
author_facet Morrissey, C. Orla
author_sort Morrissey, C. Orla
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description Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure even with the availability of new more potent and less toxic antifungal agents. New non-culture-based serological and PCR assays have been developed. These appear more sensitive and are able to make an earlier diagnosis as compared with traditional diagnostic methods. Early diagnosis is central to reducing IFI-related morbidity and mortality. This review describes the diagnostic potential of the new serological and PCR assays and outlines how these assays have been incorporated into algorithms to improve the management of IFI.
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spelling pubmed-35684822013-02-14 Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections Morrissey, C. Orla Curr Fungal Infect Rep Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor) Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure even with the availability of new more potent and less toxic antifungal agents. New non-culture-based serological and PCR assays have been developed. These appear more sensitive and are able to make an earlier diagnosis as compared with traditional diagnostic methods. Early diagnosis is central to reducing IFI-related morbidity and mortality. This review describes the diagnostic potential of the new serological and PCR assays and outlines how these assays have been incorporated into algorithms to improve the management of IFI. Current Science Inc. 2013-01-11 2013 /pmc/articles/PMC3568482/ /pubmed/23420637 http://dx.doi.org/10.1007/s12281-012-0128-4 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor)
Morrissey, C. Orla
Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
title Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
title_full Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
title_fullStr Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
title_full_unstemmed Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
title_short Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
title_sort advancing the field: evidence for new management strategies in invasive fungal infections
topic Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568482/
https://www.ncbi.nlm.nih.gov/pubmed/23420637
http://dx.doi.org/10.1007/s12281-012-0128-4
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