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Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections
Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Current Science Inc.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568482/ https://www.ncbi.nlm.nih.gov/pubmed/23420637 http://dx.doi.org/10.1007/s12281-012-0128-4 |
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author | Morrissey, C. Orla |
author_facet | Morrissey, C. Orla |
author_sort | Morrissey, C. Orla |
collection | PubMed |
description | Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure even with the availability of new more potent and less toxic antifungal agents. New non-culture-based serological and PCR assays have been developed. These appear more sensitive and are able to make an earlier diagnosis as compared with traditional diagnostic methods. Early diagnosis is central to reducing IFI-related morbidity and mortality. This review describes the diagnostic potential of the new serological and PCR assays and outlines how these assays have been incorporated into algorithms to improve the management of IFI. |
format | Online Article Text |
id | pubmed-3568482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Current Science Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35684822013-02-14 Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections Morrissey, C. Orla Curr Fungal Infect Rep Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor) Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in the immunocompromised. The traditional diagnostic methods of culture and histological examination lack sensitivity and often only make a diagnosis late when the fungal burden is high, reducing the chances of cure even with the availability of new more potent and less toxic antifungal agents. New non-culture-based serological and PCR assays have been developed. These appear more sensitive and are able to make an earlier diagnosis as compared with traditional diagnostic methods. Early diagnosis is central to reducing IFI-related morbidity and mortality. This review describes the diagnostic potential of the new serological and PCR assays and outlines how these assays have been incorporated into algorithms to improve the management of IFI. Current Science Inc. 2013-01-11 2013 /pmc/articles/PMC3568482/ /pubmed/23420637 http://dx.doi.org/10.1007/s12281-012-0128-4 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor) Morrissey, C. Orla Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections |
title | Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections |
title_full | Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections |
title_fullStr | Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections |
title_full_unstemmed | Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections |
title_short | Advancing the Field: Evidence for New Management Strategies in Invasive Fungal Infections |
title_sort | advancing the field: evidence for new management strategies in invasive fungal infections |
topic | Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568482/ https://www.ncbi.nlm.nih.gov/pubmed/23420637 http://dx.doi.org/10.1007/s12281-012-0128-4 |
work_keys_str_mv | AT morrisseycorla advancingthefieldevidencefornewmanagementstrategiesininvasivefungalinfections |