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Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I
Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data con...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568865/ https://www.ncbi.nlm.nih.gov/pubmed/23431316 http://dx.doi.org/10.1155/2013/352689 |
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author | Qiong-Hua, Pan Zhong-Yi, Zheng Jun, Yang Yan, Wen Lian-Chao, Yuan Huan-Ying, Li Reed, Steven G. Duthie, Malcolm S. |
author_facet | Qiong-Hua, Pan Zhong-Yi, Zheng Jun, Yang Yan, Wen Lian-Chao, Yuan Huan-Ying, Li Reed, Steven G. Duthie, Malcolm S. |
author_sort | Qiong-Hua, Pan |
collection | PubMed |
description | Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination. Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis. |
format | Online Article Text |
id | pubmed-3568865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35688652013-02-21 Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I Qiong-Hua, Pan Zhong-Yi, Zheng Jun, Yang Yan, Wen Lian-Chao, Yuan Huan-Ying, Li Reed, Steven G. Duthie, Malcolm S. J Trop Med Clinical Study Leprosy is a disabling chronic infection, with insidious onset that often evades early detection. In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent. Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1. Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations. Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination. Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis. Hindawi Publishing Corporation 2013 2013-01-28 /pmc/articles/PMC3568865/ /pubmed/23431316 http://dx.doi.org/10.1155/2013/352689 Text en Copyright © 2013 Pan Qiong-Hua et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Qiong-Hua, Pan Zhong-Yi, Zheng Jun, Yang Yan, Wen Lian-Chao, Yuan Huan-Ying, Li Reed, Steven G. Duthie, Malcolm S. Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_full | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_fullStr | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_full_unstemmed | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_short | Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I |
title_sort | early revelation of leprosy in china by sequential antibody analyses with lid-1 and pgl-i |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568865/ https://www.ncbi.nlm.nih.gov/pubmed/23431316 http://dx.doi.org/10.1155/2013/352689 |
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