Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

Alpha-synucleinopathies (ASP) are neurodegenerative disorders, characterized by accumulation of misfolded α-synuclein, selective neuronal loss, and extensive gliosis. It is accepted that microgliosis and astrogliosis contribute to the disease progression in ASP. Toll-like receptors (TLRs) are expres...

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Detalles Bibliográficos
Autores principales: Fellner, Lisa, Irschick, Regina, Schanda, Kathrin, Reindl, Markus, Klimaschewski, Lars, Poewe, Werner, Wenning, Gregor K, Stefanova, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568908/
https://www.ncbi.nlm.nih.gov/pubmed/23108585
http://dx.doi.org/10.1002/glia.22437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568908/
https://www.ncbi.nlm.nih.gov/pubmed/23108585
http://dx.doi.org/10.1002/glia.22437

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