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Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects

OBJECTIVE: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effe...

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Autores principales: Watanabe, Shin-ya, Iga, Jun-ichi, Numata, Shusuke, Nakataki, Masahito, Tanahashi, Toshihito, Itakura, Mitsuo, Ohmori, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569167/
https://www.ncbi.nlm.nih.gov/pubmed/23431037
http://dx.doi.org/10.9758/cpn.2012.10.3.185
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author Watanabe, Shin-ya
Iga, Jun-ichi
Numata, Shusuke
Nakataki, Masahito
Tanahashi, Toshihito
Itakura, Mitsuo
Ohmori, Tetsuro
author_facet Watanabe, Shin-ya
Iga, Jun-ichi
Numata, Shusuke
Nakataki, Masahito
Tanahashi, Toshihito
Itakura, Mitsuo
Ohmori, Tetsuro
author_sort Watanabe, Shin-ya
collection PubMed
description OBJECTIVE: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects. METHODS: Three hundred fifty one patients with schizophrenia and 342 age- and sex-matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays. RESULTS: There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects. CONCLUSION: Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects, but might not have same impacts on the BMI of patients with schizophrenia.
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spelling pubmed-35691672013-02-21 Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects Watanabe, Shin-ya Iga, Jun-ichi Numata, Shusuke Nakataki, Masahito Tanahashi, Toshihito Itakura, Mitsuo Ohmori, Tetsuro Clin Psychopharmacol Neurosci Original Article OBJECTIVE: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects. METHODS: Three hundred fifty one patients with schizophrenia and 342 age- and sex-matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays. RESULTS: There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects. CONCLUSION: Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects, but might not have same impacts on the BMI of patients with schizophrenia. Korean College of Neuropsychopharmacology 2012-12 2012-12-20 /pmc/articles/PMC3569167/ /pubmed/23431037 http://dx.doi.org/10.9758/cpn.2012.10.3.185 Text en Copyright© 2012, Korean College of Neuropsychopharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Watanabe, Shin-ya
Iga, Jun-ichi
Numata, Shusuke
Nakataki, Masahito
Tanahashi, Toshihito
Itakura, Mitsuo
Ohmori, Tetsuro
Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects
title Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects
title_full Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects
title_fullStr Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects
title_full_unstemmed Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects
title_short Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects
title_sort association study of fat-mass and obesity-associated gene and body mass index in japanese patients with schizophrenia and healthy subjects
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569167/
https://www.ncbi.nlm.nih.gov/pubmed/23431037
http://dx.doi.org/10.9758/cpn.2012.10.3.185
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