Differential Roles of Hath1, MUC2 and P27Kip1 in Relation with Gamma-Secretase Inhibition in Human Colonic Carcinomas: A Translational Study

Hath1, a bHLH transcription factor negatively regulated by the γ-secretase-dependent Notch pathway, is required for intestinal secretory cell differentiation. Our aim was fourfold: 1) determine whether Hath1 is able to alter the phenotype of colon cancer cells that are committed to a differentiated...

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Detalles Bibliográficos
Autores principales: Souazé, Frédérique, Bou-Hanna, Chantal, Kandel, Christine, Leclair, François, Devallière, Julie, Charreau, Béatrice, Bézieau, Stéphane, Mosnier, Jean-François, Laboisse, Christian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569436/
https://www.ncbi.nlm.nih.gov/pubmed/23409082
http://dx.doi.org/10.1371/journal.pone.0055904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569436/
https://www.ncbi.nlm.nih.gov/pubmed/23409082
http://dx.doi.org/10.1371/journal.pone.0055904

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