Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y

The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neur...

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Detalles Bibliográficos
Autores principales: Yusuf, Mohammed, Leung, Kay, Morris, Keith J., Volpi, Emanuela V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569589/
https://www.ncbi.nlm.nih.gov/pubmed/23224213
http://dx.doi.org/10.1007/s10048-012-0350-9
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author Yusuf, Mohammed
Leung, Kay
Morris, Keith J.
Volpi, Emanuela V.
author_facet Yusuf, Mohammed
Leung, Kay
Morris, Keith J.
Volpi, Emanuela V.
author_sort Yusuf, Mohammed
collection PubMed
description The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neuronal phenotype. This property has conferred them the potential to be used as an in vitro model for studies of neurodegenerative and neurodevelopmental disorders. Here, we present a comprehensive assessment of the SH-SY5Y cytogenomic profile. Our results advocate for molecular cytogenetic data to inform the use of cancer cell lines in research.
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spelling pubmed-35695892013-02-14 Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y Yusuf, Mohammed Leung, Kay Morris, Keith J. Volpi, Emanuela V. Neurogenetics Short Communication The widely studied SH-SY5Y human neuroblastoma cell line provides a classic example of how a cancer cell line can be instrumental for discoveries of broad biological and clinical significance. An important feature of the SH-SY5Y cells is their ability to differentiate into a functionally mature neuronal phenotype. This property has conferred them the potential to be used as an in vitro model for studies of neurodegenerative and neurodevelopmental disorders. Here, we present a comprehensive assessment of the SH-SY5Y cytogenomic profile. Our results advocate for molecular cytogenetic data to inform the use of cancer cell lines in research. Springer-Verlag 2012-12-09 2013 /pmc/articles/PMC3569589/ /pubmed/23224213 http://dx.doi.org/10.1007/s10048-012-0350-9 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Yusuf, Mohammed
Leung, Kay
Morris, Keith J.
Volpi, Emanuela V.
Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
title Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
title_full Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
title_fullStr Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
title_full_unstemmed Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
title_short Comprehensive cytogenomic profile of the in vitro neuronal model SH-SY5Y
title_sort comprehensive cytogenomic profile of the in vitro neuronal model sh-sy5y
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569589/
https://www.ncbi.nlm.nih.gov/pubmed/23224213
http://dx.doi.org/10.1007/s10048-012-0350-9
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AT volpiemanuelav comprehensivecytogenomicprofileoftheinvitroneuronalmodelshsy5y

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