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Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy

Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atro...

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Autores principales: Andres-Mateos, Eva, Brinkmeier, Heinrich, Burks, Tyesha N, Mejias, Rebeca, Files, Daniel C, Steinberger, Martin, Soleimani, Arshia, Marx, Ruth, Simmers, Jessica L, Lin, Benjamin, Finanger Hedderick, Erika, Marr, Tom G, Lin, Brian M, Hourdé, Christophe, Leinwand, Leslie A, Kuhl, Dietmar, Föller, Michael, Vogelsang, Silke, Hernandez-Diaz, Ivan, Vaughan, Dana K, Alvarez de la Rosa, Diego, Lang, Florian, Cohn, Ronald D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569655/
https://www.ncbi.nlm.nih.gov/pubmed/23161797
http://dx.doi.org/10.1002/emmm.201201443
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author Andres-Mateos, Eva
Brinkmeier, Heinrich
Burks, Tyesha N
Mejias, Rebeca
Files, Daniel C
Steinberger, Martin
Soleimani, Arshia
Marx, Ruth
Simmers, Jessica L
Lin, Benjamin
Finanger Hedderick, Erika
Marr, Tom G
Lin, Brian M
Hourdé, Christophe
Leinwand, Leslie A
Kuhl, Dietmar
Föller, Michael
Vogelsang, Silke
Hernandez-Diaz, Ivan
Vaughan, Dana K
Alvarez de la Rosa, Diego
Lang, Florian
Cohn, Ronald D
author_facet Andres-Mateos, Eva
Brinkmeier, Heinrich
Burks, Tyesha N
Mejias, Rebeca
Files, Daniel C
Steinberger, Martin
Soleimani, Arshia
Marx, Ruth
Simmers, Jessica L
Lin, Benjamin
Finanger Hedderick, Erika
Marr, Tom G
Lin, Brian M
Hourdé, Christophe
Leinwand, Leslie A
Kuhl, Dietmar
Föller, Michael
Vogelsang, Silke
Hernandez-Diaz, Ivan
Vaughan, Dana K
Alvarez de la Rosa, Diego
Lang, Florian
Cohn, Ronald D
author_sort Andres-Mateos, Eva
collection PubMed
description Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy.
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spelling pubmed-35696552013-02-12 Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy Andres-Mateos, Eva Brinkmeier, Heinrich Burks, Tyesha N Mejias, Rebeca Files, Daniel C Steinberger, Martin Soleimani, Arshia Marx, Ruth Simmers, Jessica L Lin, Benjamin Finanger Hedderick, Erika Marr, Tom G Lin, Brian M Hourdé, Christophe Leinwand, Leslie A Kuhl, Dietmar Föller, Michael Vogelsang, Silke Hernandez-Diaz, Ivan Vaughan, Dana K Alvarez de la Rosa, Diego Lang, Florian Cohn, Ronald D EMBO Mol Med Research Articles Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from muscle atrophy despite prolonged periods of immobilization and starvation. Here, we describe a mechanism underlying muscle preservation and translate it to non-hibernating mammals. Although Akt has an established role in skeletal muscle homeostasis, we find that serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates muscle mass maintenance via downregulation of proteolysis and autophagy as well as increased protein synthesis during hibernation. We demonstrate that SGK1 is critical for the maintenance of skeletal muscle homeostasis and function in non-hibernating mammals in normal and atrophic conditions such as starvation and immobilization. Our results identify a novel therapeutic target to combat loss of skeletal muscle mass associated with muscle degeneration and atrophy. WILEY-VCH Verlag 2013-01 2012-11-19 /pmc/articles/PMC3569655/ /pubmed/23161797 http://dx.doi.org/10.1002/emmm.201201443 Text en Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Research Articles
Andres-Mateos, Eva
Brinkmeier, Heinrich
Burks, Tyesha N
Mejias, Rebeca
Files, Daniel C
Steinberger, Martin
Soleimani, Arshia
Marx, Ruth
Simmers, Jessica L
Lin, Benjamin
Finanger Hedderick, Erika
Marr, Tom G
Lin, Brian M
Hourdé, Christophe
Leinwand, Leslie A
Kuhl, Dietmar
Föller, Michael
Vogelsang, Silke
Hernandez-Diaz, Ivan
Vaughan, Dana K
Alvarez de la Rosa, Diego
Lang, Florian
Cohn, Ronald D
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
title Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
title_full Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
title_fullStr Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
title_full_unstemmed Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
title_short Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy
title_sort activation of serum/glucocorticoid-induced kinase 1 (sgk1) is important to maintain skeletal muscle homeostasis and prevent atrophy
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569655/
https://www.ncbi.nlm.nih.gov/pubmed/23161797
http://dx.doi.org/10.1002/emmm.201201443
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