Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

Mechanisms that alter protein phosphatase 2A (PP2A)-dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor ceramide binds I2PP2A/SET selectively in the nucleus and including its K209 and Y122 residues as determined by molecular modelling...

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Detalles Bibliográficos
Autores principales: Saddoughi, Sahar A, Gencer, Salih, Peterson, Yuri K, Ward, Katherine E, Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M, Thomas, Raquela J, Selvam, Shanmugam P, Senkal, Can E, Garrett-Mayer, Elizabeth, De Palma, Ryan M, Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A, Stahelin, Robert V, Perrotti, Danilo, Ogretmen, Besim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569657/
https://www.ncbi.nlm.nih.gov/pubmed/23180565
http://dx.doi.org/10.1002/emmm.201201283

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