4-Amino-N-(4,6-dimethyl­pyrimidin-2-yl)benzene­sulfonamide–2-nitro­benzoic acid (1/1)

In the asymmetric unit of the title co-crystal, C(12)H(14)N(4)O(2)S·C(7)H(5)NO(4), the sulfamethazine and 2-nitro­benzoic acid mol­ecules form a heterodimer through inter­molecular amide–carb­oxy­lic acid N—H⋯O and carb­oxy­lic acid–pyrimidine O—H⋯N hydrogen-bond pairs, giving a cyclic motif [graph...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Graham, Wermuth, Urs D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569767/
https://www.ncbi.nlm.nih.gov/pubmed/23424513
http://dx.doi.org/10.1107/S1600536813000779
Descripción
Sumario:In the asymmetric unit of the title co-crystal, C(12)H(14)N(4)O(2)S·C(7)H(5)NO(4), the sulfamethazine and 2-nitro­benzoic acid mol­ecules form a heterodimer through inter­molecular amide–carb­oxy­lic acid N—H⋯O and carb­oxy­lic acid–pyrimidine O—H⋯N hydrogen-bond pairs, giving a cyclic motif [graph set R (2) (2)(8)]. The dihedral angle between the two aromatic ring systems in the sulfamethazine mol­ecule is 88.96 (18)° and the nitro group of the acid is 50% rotationally disordered. Secondary aniline N—H⋯O(sulfone) hydrogen-bonding associations give a two-dimensional structure lying parallel to the ab plane.

Ejemplares similares